Review Article The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence---a review
Charles Lung-Cheng Huang
Department of Psychiatry, National Taiwan University Hospital Yun-Lin Branch and Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan.
Received March 17, 2010; accepted March 22, 2010, available online March 25, 2010
Abstract: Alcohol dependence is believed to be a multifactorial, polygenic disorder involving complex gene-gene and gene-environment interactions and confounded by heterogeneity and sociocultural factors. Serotonin (5-Hydroxytryptamine, 5-HT) is thought to be involved in many aspects of alcohol consumption, abuse, and dependence. There was some evidence that serotonin-related genes might interact with the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol dependence. In the current review, we discuss the role of serotonin and possible interaction of serotonin-related genes with ADH and ALDH genes in alcohol dependence. (AJTR1001005).
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