AJTR Copyright © 2009-All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711
Am J Translational Res 2010;2(2):190-199

Review Article
The role of serotonin and possible interaction of serotonin-related
genes with alcohol dehydrogenase and aldehyde dehydrogenase
genes in alcohol dependence---a review

Charles Lung-Cheng Huang

Department of Psychiatry, National Taiwan University Hospital Yun-Lin Branch and Graduate Institute of Medicine,
Kaohsiung Medical University, Taiwan.

Received March 17, 2010; accepted March 22, 2010, available online March 25, 2010

Abstract: Alcohol dependence is believed to be a multifactorial, polygenic disorder involving complex gene-gene
and gene-environment interactions and confounded by heterogeneity and sociocultural factors. Serotonin
(5-Hydroxytryptamine, 5-HT) is thought to be involved in many aspects of alcohol consumption, abuse, and
dependence. There was some evidence that serotonin-related genes might interact with the alcohol
dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol
dependence. In the current review, we discuss the role of serotonin and possible interaction of serotonin-related
genes with ADH and ALDH genes in alcohol dependence. (AJTR1001005).

Key words: Alcohol dependence, gene-gene interaction, 5-HT, serotonin-related genes, ADH, ALDH

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Address all correspondence to:
Charles Lung-Cheng Huang, MD
Department of Psychiatry
National Taiwan University Hospital Yun-Lin Branch
No. 579, Sec. 2, Yun-Lin Rd., Douliou City, Yun-Lin 640
Taiwan.
Tel: +886-5-5323911 ext7107
Fax: +886-6-2345501
E-mail:
psychidr@gmail.com