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Am J Translational Res 2011;3(1):48-60

Review Article
Constraint-induced movement therapy as a paradigm of translational
research in neurorehabilitation: Reviews and prospects

Wei-Chao Huang, Yun-Ju Chen, Chung-Liang Chien, Haruo Kashima, Keh-chung Lin

Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan;
Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; School of Occupational
Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; Division of Occupational Therapy,
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan

Received August 13, 2010; accepted September 26, 2010; Epub October 3, 2010; Published: January 1, 2011

Abstract: There is an increasing awareness about the importance of translation from basic scientific findings into
practical application for efficiently improving human health, especially in the pharmaceutical industry. In the field of
neurorehabilitation, however, the bench-to-bedside process continues to be developing, and thus most of the
therapeutic interventions have encountered barriers during exploration of evidence-based effectiveness. Despite
this immaturity, constraint-induced movement therapy (CIT), a well-evidenced treatment evolved from research in
nonhuman primates, is suggested to be an ideal paradigm of translational research in the field of
neurorehabilitation. This article reviews the evolvement of CIT with regards to its behavioral efficacy and
neuroimaging evidence through the translation roadmap developed by the National Institutes of Health. We also
discuss prospects for the application of combined interventions, such as stem cell therapy or pharmaceutical
prescription, with appropriate screening of patients beforehand, as well as an efficient delivery mode after the
treatment. To achieve such goals and consolidate evidenced-based neurorehabilitation, we provide a framework
for applications into the translational research of other therapeutic interventions aside from CIT. (AJTR1008002).

Key words: Neurorehabilitation, constraint-induced movement therapy, neuroimaging, translational medicine,

Full Text  PDF

Address all correspondence to:
Keh-chung Lin, ScD
School of Occupational Therapy, College of Medicine
National Taiwan University and Division of Occupational Therapy
Department of Physical Medicine and Rehabilitation
National Taiwan University Hospital
17, F4, Xu Zhou Road, Taipei, Taiwan.
Tel: +886-2-33668180, Fax: +886-2-23710614