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Am J Transl Res 2011;3(5):422-433
Review Article
Translational research: current status, challenges and future strategies
Dale Yu
18582 Crystal Canyon Road, Silverado, CA 92676, USA.
Received July 26, 2011; accepted August 29, 2011; Epub September 12, 2011; Published October 31, 2011
Abstract: Advances in translational research are expected to mitigate the recent drought in new drug
development. Despite significant progress recently made in biological sciences, the results are decidedly mixed
with significant breakthrough in some disease areas while extensive work remains to be completed in other
areas. This review article provides a general survey of the current landscape of translational research so as to
identify progress and areas of needs and the associated strategy. While significant advances in the development
of translational tools have been made in all fronts, the availability of predictive preclinical models remains critical
for the success of translational research. This is directly correlated with the success of translational research as
illustrated by the recent approval of targeted drug therapies. By the same logic, unexpected side effects can also
be explained by laboratory findings, thus completing the translational cycle. Because of this reason, further
collaboration between preclinical and clinical scientists is essential. Non-scientific issues have important
influence on the future of this endeavor cannot be underestimated either. Nonetheless, with definitive
commitment of private industry and public resources, the future of translational research is promising.
(AJTR1107005).
Keywords: Translational research, review
Full Text PDF
Address all correspondence to:
Dale Yu, PhD
18582 Crystal Canyon Road, Silverado
CA 92676, USA.
Phone: (949) 858-2280
E-mail: dalekyu@yahoo.com
Review Article
Translational research: current status, challenges and future strategies
Dale Yu
18582 Crystal Canyon Road, Silverado, CA 92676, USA.
Received July 26, 2011; accepted August 29, 2011; Epub September 12, 2011; Published October 31, 2011
Abstract: Advances in translational research are expected to mitigate the recent drought in new drug
development. Despite significant progress recently made in biological sciences, the results are decidedly mixed
with significant breakthrough in some disease areas while extensive work remains to be completed in other
areas. This review article provides a general survey of the current landscape of translational research so as to
identify progress and areas of needs and the associated strategy. While significant advances in the development
of translational tools have been made in all fronts, the availability of predictive preclinical models remains critical
for the success of translational research. This is directly correlated with the success of translational research as
illustrated by the recent approval of targeted drug therapies. By the same logic, unexpected side effects can also
be explained by laboratory findings, thus completing the translational cycle. Because of this reason, further
collaboration between preclinical and clinical scientists is essential. Non-scientific issues have important
influence on the future of this endeavor cannot be underestimated either. Nonetheless, with definitive
commitment of private industry and public resources, the future of translational research is promising.
(AJTR1107005).
Keywords: Translational research, review
Full Text PDF
Address all correspondence to:
Dale Yu, PhD
18582 Crystal Canyon Road, Silverado
CA 92676, USA.
Phone: (949) 858-2280
E-mail: dalekyu@yahoo.com
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