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Am J Transl Res 2012;4(1):44-51
Original Article
Pterostilbene simultaneously induces apoptosis, cell cycle arrest and
cyto-protective autophagy in breast cancer cells
Yanshang Wang, Ling Ding, Xian Wang, Jingyi Zhang, Weidong Han, Lifeng Feng, Jie Sun, Hongchuan Jin, Xiao
Jia Wang
Department of Medical Oncology, Cancer Hospital of Zhejiang Province, Hangzhou, China; Laboratory of Cancer
Epigenetics, Biomedical Research center, Sir Runrun Shaw Hospital, Medical School of Zhejiang University,
Hangzhou, China; Department of Medical Oncology, 2nd Hospital, Medical School of Zhejiang University,
Hangzhou, China
Received October 17, 2011; accepted November 20, 2011; Epub January 5, 2012; Published January 15, 2012
Abstract: As a nature phytoalexin found in grapes, resveratrol has been proposed as a potential drug for cancer
chemoprevention and treatment. However, its poor bioavailability limits its potential clinical application.
Pterostilbene, the natural dimethylated analog of resveratrol with greater bioavailability, was confirmed to inhibit
tumor growth both in vivo and in vitro, demonstrating its potential for further clinical application. In the current
study, we found that pterostilbene could markedly inhibit the growth of two independent breast cancer cell lines.
Both apoptosis and cell cycle arrest as well as the inhibition of wnt singling was induced by pterostilbene. The
dominant-active mutant of β-catenin could reverse the growth inhibitory effect of pterostilbene, indicating that the
inhibition of wnt signaling is important to the growth inhibitory effect of pterostilbene. Interestingly, pterostilbene
induced autophagy and blockage of autophagy augmented pterostilbene-induced growth inhibition, suggesting
that the combination of autophagy inhibitors with pterostilbene and other therapeutics such as endocrine drugs
could serve as a new and promising strategy for the treatment of breast cancer cells. (AJTR1110001).
Keywords: Pterostilbene, phytoalexins, tumor growth inhibition, wnt singling , apoptosis
Full Text PDF
Address all correspondence to:
Xiao Jia Wang
Department of Medical Oncology
Cancer Hospital of Zhejiang Province
Hangzhou, China.
Tel: +86 571 88122178; Fax: +86 571 88122510
E-mail: wxj88851@yahoo.com.cn;
Original Article
Pterostilbene simultaneously induces apoptosis, cell cycle arrest and
cyto-protective autophagy in breast cancer cells
Yanshang Wang, Ling Ding, Xian Wang, Jingyi Zhang, Weidong Han, Lifeng Feng, Jie Sun, Hongchuan Jin, Xiao
Jia Wang
Department of Medical Oncology, Cancer Hospital of Zhejiang Province, Hangzhou, China; Laboratory of Cancer
Epigenetics, Biomedical Research center, Sir Runrun Shaw Hospital, Medical School of Zhejiang University,
Hangzhou, China; Department of Medical Oncology, 2nd Hospital, Medical School of Zhejiang University,
Hangzhou, China
Received October 17, 2011; accepted November 20, 2011; Epub January 5, 2012; Published January 15, 2012
Abstract: As a nature phytoalexin found in grapes, resveratrol has been proposed as a potential drug for cancer
chemoprevention and treatment. However, its poor bioavailability limits its potential clinical application.
Pterostilbene, the natural dimethylated analog of resveratrol with greater bioavailability, was confirmed to inhibit
tumor growth both in vivo and in vitro, demonstrating its potential for further clinical application. In the current
study, we found that pterostilbene could markedly inhibit the growth of two independent breast cancer cell lines.
Both apoptosis and cell cycle arrest as well as the inhibition of wnt singling was induced by pterostilbene. The
dominant-active mutant of β-catenin could reverse the growth inhibitory effect of pterostilbene, indicating that the
inhibition of wnt signaling is important to the growth inhibitory effect of pterostilbene. Interestingly, pterostilbene
induced autophagy and blockage of autophagy augmented pterostilbene-induced growth inhibition, suggesting
that the combination of autophagy inhibitors with pterostilbene and other therapeutics such as endocrine drugs
could serve as a new and promising strategy for the treatment of breast cancer cells. (AJTR1110001).
Keywords: Pterostilbene, phytoalexins, tumor growth inhibition, wnt singling , apoptosis
Full Text PDF
Address all correspondence to:
Xiao Jia Wang
Department of Medical Oncology
Cancer Hospital of Zhejiang Province
Hangzhou, China.
Tel: +86 571 88122178; Fax: +86 571 88122510
E-mail: wxj88851@yahoo.com.cn;
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