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Am J Translational Res 2012;4(1):1-13
Review Article
Epithelial-mesenchymal transition in cervical carcinoma
Mei-Yi Lee, Meng-Ru Shen
Department of Pharmacology, Infectious Disease and Signaling Research Center, Department of Obstetrics &
Gynecology, Advanced Optoelectronic Technology Center, College of Medicine, National Cheng Kung University,
Tainan 70101, Taiwan.
Received November 5, 2011; accepted December 23, 2011; Epub January 1, 2012; Published January 15, 2012
Abstract: During the progression of epithelial cancer, cells usually lose epithelial characteristic features and gain
a mesenchymal phenotype. Cervical cancer is a common female malignancy worldwide. Despite the generally
good prognosis for early-stage cervical cancer patients, many patients still die as a result of metastasis and
recurrence. Epithelial-mesenchymal transition (EMT) has been implicated in the metastasis of primary tumors
and provides molecular mechanisms for cervical cancer metastasis. Here we provide an up-to-date overview
regarding the program of EMT in cervical cancer. In the stepwise progression of cervical cancer, human
papilloma viral proteins contributes to the cell transformation and the conversion of typical epithelial cells to the
epithelial carcinoma cells with hybrid epithelial and mesenchymal characteristics. Molecules related to the EMT
program of cervical cancer cells are summarized in this review paper. Several soluble factors acting on their
cognate receptors stimulate the mesenchymal transition of cervical epithelial cells. Ion transport system as well
as cytoskeletal modulators also stimulate the progression of EMT program in cervical carcinoma cells.
Transcriptional factors such as Snail, Twist1, Twist2, and six1 homeoproteins are involved in the complicated
regulation and cervical cancer metastasis. Among the various signalings associated with EMT program, Snail is
a central transcription factor which governs EMT program. In contrast to tumor promoters, there are several tumor
suppressors such as SFRP1/2 and LMX-1A have been reported to suppress tumorigenesis as well as metastatic
spread through inhibiting the EMT program. (AJTR1111001).
Keywords: Epithelial-mesenchymal transition, growth factors, transcriptional factors, cervical cancer
Full Text PDF
Address all correspondence to:
Meng-Ru Shen, MD, PhD
Department of Obstetrics & Gynecology
National Cheng Kung University Hospital
Tainan 704, Taiwan.
Phone: 886-6-2353535 ext 5505; Fax: 886-6-2766185
E-mail: mrshen@mail.ncku.edu.tw
Review Article
Epithelial-mesenchymal transition in cervical carcinoma
Mei-Yi Lee, Meng-Ru Shen
Department of Pharmacology, Infectious Disease and Signaling Research Center, Department of Obstetrics &
Gynecology, Advanced Optoelectronic Technology Center, College of Medicine, National Cheng Kung University,
Tainan 70101, Taiwan.
Received November 5, 2011; accepted December 23, 2011; Epub January 1, 2012; Published January 15, 2012
Abstract: During the progression of epithelial cancer, cells usually lose epithelial characteristic features and gain
a mesenchymal phenotype. Cervical cancer is a common female malignancy worldwide. Despite the generally
good prognosis for early-stage cervical cancer patients, many patients still die as a result of metastasis and
recurrence. Epithelial-mesenchymal transition (EMT) has been implicated in the metastasis of primary tumors
and provides molecular mechanisms for cervical cancer metastasis. Here we provide an up-to-date overview
regarding the program of EMT in cervical cancer. In the stepwise progression of cervical cancer, human
papilloma viral proteins contributes to the cell transformation and the conversion of typical epithelial cells to the
epithelial carcinoma cells with hybrid epithelial and mesenchymal characteristics. Molecules related to the EMT
program of cervical cancer cells are summarized in this review paper. Several soluble factors acting on their
cognate receptors stimulate the mesenchymal transition of cervical epithelial cells. Ion transport system as well
as cytoskeletal modulators also stimulate the progression of EMT program in cervical carcinoma cells.
Transcriptional factors such as Snail, Twist1, Twist2, and six1 homeoproteins are involved in the complicated
regulation and cervical cancer metastasis. Among the various signalings associated with EMT program, Snail is
a central transcription factor which governs EMT program. In contrast to tumor promoters, there are several tumor
suppressors such as SFRP1/2 and LMX-1A have been reported to suppress tumorigenesis as well as metastatic
spread through inhibiting the EMT program. (AJTR1111001).
Keywords: Epithelial-mesenchymal transition, growth factors, transcriptional factors, cervical cancer
Full Text PDF
Address all correspondence to:
Meng-Ru Shen, MD, PhD
Department of Obstetrics & Gynecology
National Cheng Kung University Hospital
Tainan 704, Taiwan.
Phone: 886-6-2353535 ext 5505; Fax: 886-6-2766185
E-mail: mrshen@mail.ncku.edu.tw
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