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Am J Transl Res 2012;4(3):357-363
Review Article
Krüppel-like factor 8 emerges as an important regulator of cancer
Satadru K Lahiri, Jihe Zhao
Burnett School of Biomedical Sciences, University of Central Florida College of Medicine; Burnett School of
Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA
Received July 17, 2012; accepted July 25, 2012; Epub July 27, 2012; Published August 15, 2012
Abstract: Krüppel-like factor 8 (KLF8) are a young member of the KLF transcription factor family proteins. It is
highly overexpressed in several types of human cancers and regulates various cellular processes important for
tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for
cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its
structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.
(AJTR1207004).
Keywords: Krüppel-like factor 8 (KLF8), cancer
Address all correspondence to:
Dr. Jihe Zhao
Burnett School of Biomedical Sciences
College of Medicine, University of Central Florida
Orlando, FL 32827, USA.
Tel: 407-266-7099; Fax: 407-266-7002
E-mail: jihe.zhao@ucf.edu
Review Article
Krüppel-like factor 8 emerges as an important regulator of cancer
Satadru K Lahiri, Jihe Zhao
Burnett School of Biomedical Sciences, University of Central Florida College of Medicine; Burnett School of
Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA
Received July 17, 2012; accepted July 25, 2012; Epub July 27, 2012; Published August 15, 2012
Abstract: Krüppel-like factor 8 (KLF8) are a young member of the KLF transcription factor family proteins. It is
highly overexpressed in several types of human cancers and regulates various cellular processes important for
tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for
cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its
structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.
(AJTR1207004).
Keywords: Krüppel-like factor 8 (KLF8), cancer
Address all correspondence to:
Dr. Jihe Zhao
Burnett School of Biomedical Sciences
College of Medicine, University of Central Florida
Orlando, FL 32827, USA.
Tel: 407-266-7099; Fax: 407-266-7002
E-mail: jihe.zhao@ucf.edu
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