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Am J Transl Res 2013;5(1):15-20
Review Article
Genetic modeling of ovarian phenotypes in mice for the study of
human polycystic ovary syndrome
Yi Feng, Xin Li, Ruijin Shao
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at
University of Gothenburg, Gothenburg, Sweden; Department of Integrative Medicine and Neurobiology, State Key
Laboratory of Medical Neurobiology, Shanghai Medi-cal College; Institute of Acupuncture Research (WHO
Collaborating Center for Traditional Medicine); Institutes of Brain Science, Fudan University, Shanghai, China;
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
Received November 28, 2012; Accepted December 29, 2012; Epub January 21, 2013; Published January 30, 2013
Abstract: Polycystic ovary syndrome (PCOS) presents with a range of clinical complications including
hyperandrogenism, polycystic ovaries, chronic oligo/anovulation, infertility, and metabolic alterations related to
insulin resistance. Because the mechanism by which this disorder develops is poorly understood, information
from experimental models of human disease phenotypes may help to define the mechanisms for the initiation
and development of PCOS-related pathological events. The establishment of animal models compatible with
human PCOS is challenging, and applying the lessons learned from these models to human PCOS is often
complicated. In this mini-review we provide exam-ples of currently available genetic mouse models, their ovarian
phenotypes, and their possible relationship to different aspects of human PCOS. Because of the practical and
ethical limitations of studying PCOS-related events in humans, our understanding of the mechanisms that
contribute to the etiology of human PCOS may be enhanced through further study of these transgenic and
knockout mouse models. (AJTR1211009).
Keywords: PCOS, hemorrhagic cystic follicles, transgenic and knockout mice
Address Correspondence to: Dr. Ruijin Shao, Department of Physiology/Endocrinology, Institute of Neuroscience
and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. Phone: +46-31
7863408; Fax: +46-31 7863512; E-mail: ruijin.shao@fysiologi.gu.se
Review Article
Genetic modeling of ovarian phenotypes in mice for the study of
human polycystic ovary syndrome
Yi Feng, Xin Li, Ruijin Shao
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at
University of Gothenburg, Gothenburg, Sweden; Department of Integrative Medicine and Neurobiology, State Key
Laboratory of Medical Neurobiology, Shanghai Medi-cal College; Institute of Acupuncture Research (WHO
Collaborating Center for Traditional Medicine); Institutes of Brain Science, Fudan University, Shanghai, China;
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
Received November 28, 2012; Accepted December 29, 2012; Epub January 21, 2013; Published January 30, 2013
Abstract: Polycystic ovary syndrome (PCOS) presents with a range of clinical complications including
hyperandrogenism, polycystic ovaries, chronic oligo/anovulation, infertility, and metabolic alterations related to
insulin resistance. Because the mechanism by which this disorder develops is poorly understood, information
from experimental models of human disease phenotypes may help to define the mechanisms for the initiation
and development of PCOS-related pathological events. The establishment of animal models compatible with
human PCOS is challenging, and applying the lessons learned from these models to human PCOS is often
complicated. In this mini-review we provide exam-ples of currently available genetic mouse models, their ovarian
phenotypes, and their possible relationship to different aspects of human PCOS. Because of the practical and
ethical limitations of studying PCOS-related events in humans, our understanding of the mechanisms that
contribute to the etiology of human PCOS may be enhanced through further study of these transgenic and
knockout mouse models. (AJTR1211009).
Keywords: PCOS, hemorrhagic cystic follicles, transgenic and knockout mice
Address Correspondence to: Dr. Ruijin Shao, Department of Physiology/Endocrinology, Institute of Neuroscience
and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. Phone: +46-31
7863408; Fax: +46-31 7863512; E-mail: ruijin.shao@fysiologi.gu.se
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