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Am J Transl Res 2013;5(4):379-392
Review Article
Novel autoantigens in type 1 diabetes
Shuhong Han, William Donelan, Hai Wang, Westley Reeves, Li-Jun Yang
Department of Medicine, Pathology, Immunology and Laboratory Medicine, University of Florida College of
Medicine, Gainesville, Florida 32610, USA; Tianjin University of Science & Technology, Tianjin, 300457, China
Received April 5, 2013; Accepted May 3, 2013; Epub May 24, 2013; Published June 1, 2013
Abstract: Type 1 diabetes mellitus (T1DM) is characterized by recognition of beta cell proteins as self-antigens,
called autoantigens (AAgs), by patients’ own CD4+ and CD8+ T cells and/or the products of self-reactive B cells,
called autoantibodies. These AAgs are divided into two categories on the basis of beta-cell-specificity. The list of
the targets associated with beta cell-specific AAgs is continuously growing. Many T1DM-associated AAgs are well
characterized and have important clinical applications for disease prediction, diagnosis, and antigen-specific
tolerance immunotherapy. Identification of T1DM-associated AAgs provides insight into the pathogenesis of
T1DM and to understanding the clinical aspects of the disease. Since many excellent reviews have covered the
previously identified T1DM-associated AAgs exhaustedly, here we only focus on several recently discovered
T1DM-AAgs (PDX1, ZnT8, CHGA, and IAAP). (AJTR1304006).
Keywords: Type 1 diabetes, autoantigen, autoantibodies, Pdx1, ZnT8, IAPP, CHGA, immunotherapy, immune
tolerance
Address correspondence to: Dr. Li-Jun Yang, Department of Pathology, Immunology and Laboratory Medicine,
University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100275, Gainesville, FL 32610, USA.
Phone: 352-392-0005; E-mail: yanglj@pathology.ufl.edu
Review Article
Novel autoantigens in type 1 diabetes
Shuhong Han, William Donelan, Hai Wang, Westley Reeves, Li-Jun Yang
Department of Medicine, Pathology, Immunology and Laboratory Medicine, University of Florida College of
Medicine, Gainesville, Florida 32610, USA; Tianjin University of Science & Technology, Tianjin, 300457, China
Received April 5, 2013; Accepted May 3, 2013; Epub May 24, 2013; Published June 1, 2013
Abstract: Type 1 diabetes mellitus (T1DM) is characterized by recognition of beta cell proteins as self-antigens,
called autoantigens (AAgs), by patients’ own CD4+ and CD8+ T cells and/or the products of self-reactive B cells,
called autoantibodies. These AAgs are divided into two categories on the basis of beta-cell-specificity. The list of
the targets associated with beta cell-specific AAgs is continuously growing. Many T1DM-associated AAgs are well
characterized and have important clinical applications for disease prediction, diagnosis, and antigen-specific
tolerance immunotherapy. Identification of T1DM-associated AAgs provides insight into the pathogenesis of
T1DM and to understanding the clinical aspects of the disease. Since many excellent reviews have covered the
previously identified T1DM-associated AAgs exhaustedly, here we only focus on several recently discovered
T1DM-AAgs (PDX1, ZnT8, CHGA, and IAAP). (AJTR1304006).
Keywords: Type 1 diabetes, autoantigen, autoantibodies, Pdx1, ZnT8, IAPP, CHGA, immunotherapy, immune
tolerance
Address correspondence to: Dr. Li-Jun Yang, Department of Pathology, Immunology and Laboratory Medicine,
University of Florida College of Medicine, 1600 SW Archer Road, P.O. Box 100275, Gainesville, FL 32610, USA.
Phone: 352-392-0005; E-mail: yanglj@pathology.ufl.edu
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