Review Article 14-3-3σ, the double-edged sword of human cancers
Zhaomin Li, Jingyuan Liu, and Jian-Ting Zhang
Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202., USA
Received May 28, 2009; accepted June 2, 2009; available online June 8, 2009
Abstract: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA damages. The increased expression of 14-3-3σ may also predict poor prognosis in some human cancers. Thus, 14-3-3σ may play an important role as a double-edged sword in human cancers, which may attribute to its property as a molecular chaperone by binding to various protein ligands important to many cellular processes such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will review recent studies and progresses in understanding 14-3-3σ as a double-edged sword in human cancers. (AJTR905005).
Key words: 14-3-3σ, tumorigenesis, metastasis, prognosis, drug resistance, expression regulation
Address all correspondence to: Jian-Ting Zhang, PhD IUSCC, Indiana University School of Medicine 980 W. Walnut Street, R3-C510, Indianapolis, IN 46202 Tel (317) 278-4503 Fax (317) 274-8046 E-mail: firstname.lastname@example.org