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Am J Transl Res 2009;1(4):326-340
Review Article
14-3-3σ, the double-edged sword of human cancers
Zhaomin Li, Jingyuan Liu, and Jian-Ting Zhang
Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University
School of Medicine, Indianapolis, IN 46202., USA
Received May 28, 2009; accepted June 2, 2009; available online June 8, 2009
Abstract: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic
organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human
cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA
damages. The increased expression of 14-3-3σ may also predict poor prognosis in some human cancers. Thus,
14-3-3σ may play an important role as a double-edged sword in human cancers, which may attribute to its
property as a molecular chaperone by binding to various protein ligands important to many cellular processes
such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will
review recent studies and progresses in understanding 14-3-3σ as a double-edged sword in human cancers.
(AJTR905005).
Key words: 14-3-3σ, tumorigenesis, metastasis, prognosis, drug resistance, expression regulation
Full Text PDF
Address all correspondence to:
Jian-Ting Zhang, PhD
IUSCC, Indiana University School of Medicine
980 W. Walnut Street, R3-C510, Indianapolis, IN 46202
Tel (317) 278-4503
Fax (317) 274-8046
E-mail: jianzhan@iupui.edu
Review Article
14-3-3σ, the double-edged sword of human cancers
Zhaomin Li, Jingyuan Liu, and Jian-Ting Zhang
Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University
School of Medicine, Indianapolis, IN 46202., USA
Received May 28, 2009; accepted June 2, 2009; available online June 8, 2009
Abstract: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic
organisms. 14-3-3σ has been considered as a tumor suppressor with reduced expression in some human
cancers while its increased expression causes resistance to anticancer agents and radiation that cause DNA
damages. The increased expression of 14-3-3σ may also predict poor prognosis in some human cancers. Thus,
14-3-3σ may play an important role as a double-edged sword in human cancers, which may attribute to its
property as a molecular chaperone by binding to various protein ligands important to many cellular processes
such as cell cycle checkpoint regulation and apoptosis in response to DNA damages. In this article, we will
review recent studies and progresses in understanding 14-3-3σ as a double-edged sword in human cancers.
(AJTR905005).
Key words: 14-3-3σ, tumorigenesis, metastasis, prognosis, drug resistance, expression regulation
Full Text PDF
Address all correspondence to:
Jian-Ting Zhang, PhD
IUSCC, Indiana University School of Medicine
980 W. Walnut Street, R3-C510, Indianapolis, IN 46202
Tel (317) 278-4503
Fax (317) 274-8046
E-mail: jianzhan@iupui.edu
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